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Disrupted proprioceptive timing estimates contribute to upper limb motor impairment in chronic strokeNARA Subscribed
In this task, the participants' ( p < 0.01) and variability ( p < 0.01) than controls, indicating impaired proprioceptive timing in a task that did not require active motor output from the tested limb. Larger proprioceptive timing errors were strongly correlated with poor performance on VGR (ρ > 0.57, p < 0.01) and APM in individuals with stroke (ρ > 0.49, p < 0.01). These results suggest that the estimation of timing for dyna...
Effect of Parametric Variation of Chordae Tendineae Structure on Simulated Atrioventricular Valve ClosureNARA Subscribed
Purpose Many approaches have been used to model chordae tendineae geometries in finite element simulations of atrioventricular heart valves. Unfortunately, current “functional" chordae tendineae geometries lack anatomical fidelity (e.g., branching) that would be helpful when informing clinical decisions. The objectives of this work are (i) to improve synthetic chordae tendineae geometric fidelity to consider branching and (ii)...
Pharmacokinetics and Pharmacodynamics of Nomlabofusp in Non-clinical Studies of Friedreich’s AtaxiaNARA Subscribed
Nomlabofusp is a cell penetrant peptide-based recombinant fusion protein designed to enter cells and deliver human frataxin into the mitochondria of adults and children with Friedreich’s ataxia. In this article we present non-clinical studies evaluating the pharmacology of nomlabofusp, including in a murine striated muscle tissue frataxin knockout model of Friedreich’s ataxia. We demonstrate that subcutaneous administration of...
Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. To address this...
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...
Impacts of Weather Anomalies and Climate on Plant DiseaseNARA Subscribed
Predicting the effects of climate change on plant disease is critical for protecting ecosystems and food production. Here, we show how disease pressure responds to short‐term weather, historical climate and weather anomalies by compiling a global database (4339 plant–disease populations) of disease prevalence in both agricultural and wild plant systems. We hypothesised that weather and climate would play a larger role in disea...
Dominance and rarity in tree communities across the globe: Patterns, predictors and threatsNARA Subscribed
Aim Ecological and anthropogenic factors shift the abundances of dominant and rare tree species within local forest communities, thus affecting species composition and ecosystem functioning. To inform forest and conservation management it is important to understand the drivers of dominance and rarity in local tree communities. We answer the following research questions: (1) What are the patterns of dominance and rarity in tree...
Sea turtles are a taxon of conservation concern and are highly migratory, exposing them to a variety of threats (e.g., fisheries bycatch, direct harvest) across their lifetime. Understanding the abundance of nesting females, hatchling production, and migratory movements - three of the most basic biological data needs for this species group - is imperative for population assessment. This study summarizes novel data most relevan...
The Southern California Borderland hosts a variety of geologic and oceanographic features that allow for diverse habitats to occur in a restricted region with a strong oxygen minimum zone (OMZ) and hard substrates. These include ferromanganese (FeMn) crusts and phosphorites targeted for deep‐seabed mining in other regions. Baseline studies regarding hardground macro‐ (> 0.3 mm) and megafaunal (> 2 cm) invertebrates are lacking...
Reading tea leaves worldwide: Decoupled drivers of initial litter decomposition mass‐loss rate and stabilizationNARA Subscribed
The breakdown of plant material fuels soil functioning and biodiversity. Currently, process understanding of global decomposition patterns and the drivers of such patterns are hampered by the lack of coherent large‐scale datasets. We buried 36,000 individual litterbags (tea bags) worldwide and found an overall negative correlation between initial mass‐loss rates and stabilization factors of plant‐derived carbon, using the Tea...
Geostatistical capture–recapture modelsNARA Subscribed