Long non-coding RNAs (lncRNAs) have emerged as essential regulators of gene expression, significantly influencing various biological processes. Approximately half of all lncRNAs are classified as long intergenic non-coding RNAs (lincRNAs), which are situated among coding genes. Recent studies have documented the role of lincRNAs in the pathogenesis of lung diseases, including lung cancer, pulmonary fibrosis, and pulmonary arte...

Escherichia coli O157:H7 has been linked to intestinal infections in humans and is thought to be a major cause of foodborne illnesses. The research is providing an update on the prevalence and toxin profile of multidrug-resistant E. coli O157:H7 in Upper Egypt, from November 2023 to February 2024. A total of 410 samples were obtained from food products, animals, water, and human stool for isolation, identification, and serotyp...

Allergic conjunctivitis (AC) is the most common inflammatory disease affecting the eye's ocular surface, lid, conjunctiva, and cornea. However, effective ocular drug delivery remains challenging due to physiological barriers such as the corneal barrier. Ketotifen (KF), a widely used antihistamine and mast cell stabilizer, for treating AC and atopic asthma but belongs to the Biopharmaceutical Classification System (BCS II) have...

The in-pond raceway system (IPRS), is an intensive aquaculture technology that has gained attention in recent years. This study evaluated the comparative effects of In-Pond Raceway Systems (IPRS) and traditional aquaculture systems on oxidative status, stress indices, and biomarkers of liver and kidney function, as well as proteinogram in Nile tilapia (Oreochromis niloticus) over 2, 4, and 6 months. The results revealed that s...

Depression, a devastating brain illness, necessitates the exploration of novel antidepressant treatments. We evaluated the antidepressant effects of free curcumin, zinc oxide nanoparticles (ZnO NPs), and curcumin-conjugated zinc oxide nanoparticles (Zn(cur)O NPs). The nanoformulations were extensively characterized using advanced techniques. An acute toxicity study ensured the safety of Zn(cur)O NPs. Rats were assigned to one...

Aquaculture has become a crucial solution for addressing food scarcity worldwide, including Egypt. However, the intensification of aquaculture practices has led to water quality degradation and the emergence of new fish diseases, such as vibriosis . This study aimed to investigate the molecular typing, prevalence, pathogenicity, and environmental risk factors associated with Vibrio campbellii ( V. campbellii ) in cultured seab...