Functionally constrained genes are ideal insecticide targets because disruption is often fatal, and resistance mutations are typically costly. Synaptic acetylcholinesterase ( AC hE) is an essential neurotransmission enzyme targeted by insecticides used increasingly in malaria control. In Anopheles and Culex mosquitoes, a glycine–serine substitution at codon 119 of the Ace‐1 gene confers both resistance and fitness costs, espec...

Sea level is one of the 50 Essential Climate Variables (ECVs) listed by the Global Climate Observing System (GCOS) in climate change monitoring. In the past two decades, sea level has been routinely measured from space using satellite altimetry techniques. In order to address a number of important scientific questions such as "Is sea level rise accelerating?", "Can we close the sea level budget?", "What are the causes of the r...