Rationale Psilocybin shows promise for treating neuropsychiatric disorders. However, insight into its acute effects on cognition is lacking. Given the significant role of executive functions in daily life and treatment efficacy, it is crucial to evaluate how psilocybin influences these cognitive domains. Objectives This meta-analysis aims to quantify the acute effects of psilocybin on executive functions and attention, while e...

Key message We find evidence of selection for local adaptation and extensive genotype-by-environment interaction in the potato National Chip Processing Trial (NCPT). Abstract We present a novel method for dissecting the interplay between selection, local adaptation and environmental response in plant breeding schemes. Balancing local adaptation and the desire for widely adapted cultivars is challenging for plant breeders and m...

Recent extremes of flood and drought across Australia have raised questions about the recurrence of such rare events and highlighted the importance of understanding multi-decadal climate variability. However, instrumental records over the past century are too short to adequately characterise climate variability on multi-decadal and longer timescales or robustly determine extreme event frequencies and their duration. Palaeoclim...

Structure-based grouping of chemicals for targeted testing and read-across is an efficient way to reduce resources and animal usage. For substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs), structure-based grouping is virtually impossible. Biology-based approaches such as metabolomics could provide a solution. Here, 15 steam-cracked distillates, registered in the EU through...