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Lethal organophosphate (OP) exposure leads to status epilepticus (SE), which, despite standard-of-care (SOC) therapy, is associated with acute mortality and long-term morbidities. Neuronal injury and inflammation are reported following OP-SE, and drugs targeted at these processes have produced beneficial outcomes. Verapamil (VPM) is a calcium-channel blocker used as an antihypertensive drug and has been shown to exhibit neurop...
Operant social self-administration in male CD1 miceNARA Subscribed
Rationale and Objective We recently introduced a model of operant social reward in which female CD1 mice lever press for access to affiliative social interaction with a cagemate peer mouse of the same sex and strain. Here we determined the generality of the operant social self-administration model to male CD1 mice who, under certain conditions, will lever press to attack a subordinate male mouse. Methods We trained male CD1 mi...
Responses of a federally threatened shorebird to trophic downgrading and expansion of domestic cats (Felis catus)NARA Subscribed
Along U.S. Atlantic and Gulf Coast barrier islands, red foxes ( Vulpes vulpes ) are top predators that are thought to impact smaller mesopredators and depredate beach-nesting birds. Starting in 2015, sarcoptic mange epizootics among red foxes led to their eventual temporary extirpation from most of Fire Island, NY, USA. We monitored the subsequent changes to the mammalian predator community on this barrier island and explored...
The use of unique markers in ornithology has a long history and is predicated on the assumption that markers have negligible effects on behavior and survival. The assumption that marks are harmless is particularly important with imperiled species. We studied the effects of two different marking schemes on Piping Plovers ( Charadrius melodus ), a small shorebird protected under the U.S. Endangered Species Act that is intensivel...
A framework to support the identification of critical habitat for wide-ranging species at risk under climate changeNARA Subscribed
To recover species at risk, it is necessary to identify habitat critical to their recovery. Challenges for species with large ranges (thousands of square kilometres) include delineating management unit boundaries within which habitat use differs from other units, along with assessing any differences among units in amounts of and threats to habitat over time. We developed a reproducible framework to support identification of cr...
Nonequilibrium spherulitic magnetite in the Ryugu samplesNARA Subscribed
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
The differing role of weather systems in southern Australian rainfall between 1979–1996 and 1997–2015NARA Subscribed
Most of the rainfall in southern Australia is associated with cyclones, cold fronts, and thunderstorms, and cases when these weather systems co-occur are particularly likely to cause extreme rainfall. Rainfall declines in some parts of southern Australia during the cool half of the year in recent decades have previously been attributed to decreases in the rainfall from fronts and/or cyclones, while thunderstorm-related rainfal...
Interactions between sediment microbial ecology and physical dynamics drive heterogeneity in contextually similar depositional systemsNARA Subscribed
This study focuses on the interactions between sediment stability and biological and physical variables that influence the erodibility across different habitats. Sampling at short‐term temporal scales illustrated the persistence of the microphytobenthos (MPB) biomass even during periods of frequent, high physical disturbance. The role of MPB in biological stabilization along the changing sedimentary habitat was also assessed....
A systematic analysis of the main weather types influencing southern Australian rainfall is presented for the period 1979–2015. This incorporates two multi-method datasets of cold fronts and low pressure systems, which indicate the more robust fronts and lows as distinguished from the weaker and less impactful events that are often indicated only by a single method. The front and low pressure system datasets are then combined...
Sediment cores were retrieved from Lake Kutubu, the largest upland lake in Papua New Guinea, to assess palaeoenvironmental baselines. Two prominent tephra layers were encountered within the cores. Using a combination of core stratigraphy, sediment properties and geochemical characterization (electron microprobe and laser ablation inductively coupled‐plasma mass spectrometry techniques) we were able to correlate these tephras w...
The contribution of community wisdom to conservation ecologyNARA Subscribed
Scientists have traditionally collected data on whether a population is increasing, decreasing, or staying the same, but such studies are often limited by geographic scale and time frame. This means that for many species, understanding of trends comes from only part of their ranges at particular periods. Working with citizen scientists has the potential to overcome these limits. Citizen science has the added benefit of exposin...