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NARA Subscribed2
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Springer Nature2
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Medicinal Chemistry Research2
Publication Year
20232
S. Kickinger results 2 · Newest (Page 1/1, per page 25)
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Correction: Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserineNARA Subscribed
Medicinal Chemistry Research · 2023 · Vol. 32 · Issue 12 · Springer
F. Bavo; S. Kickinger; M. E. K. Lie; C. Avgerinos; Y Xu; K. S. Wilhelmsen; P. Wellendorph; B. Frølund
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Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserineNARA Subscribed
Medicinal Chemistry Research · 2023 · Vol. 32 · Issue 11 · Springer
F. Bavo; S. Kickinger; M. E. K. Lie; C. Avgerinos; Y Xu; K. S. Wilhelmsen; P. Wellendorph; B. Frølund
The GABA transporter 3 (GAT3) is a member of the GABA transporter (GAT) family proposed to have a role in regulating tonic inhibition. The GAT3-preferring substrate ( S )-isoserine has shown beneficial effects in a mouse model of stroke accompanied by an increased GAT3 expression, indicating a molecular mechanism mediated by GAT3. However, ( S )-isoserine is not ideally suited for in vivo studies due to a lack of selectivity a...
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