In this article, we summarise recent developments, identify gaps, and propose a research agenda for quantitative health impact assessment (HIA) of environmental exposures linked to urban transport and land use. This is based on a workshop of 30 experts, complemented by targeted literature identified by participants to illustrate the state of research and practice gaps. The practice of quantitative HIA in urban transport and la...

Conventional zolmitriptan (ZOL) has limited oral bioavailability, many adverse effects, and poor membrane penetrability that negatively influences its accessibility to its 5-HT 1B/1D receptor binding pocket, located transmemberanous. This work aimed at preparing transdermal ZOL-nanoformulation (niosomes) to surpass these limitations and to explore novel antimigraine mechanisms for ZOL via modulation of the epigenetically-alter...

Background The freshwater snails Biomphalaria alexandrina and Bulinus trancatus are key contributors to the transmission of S. mansoni and S. haematobium , respectively, for being their intermediate hosts. Objectives This research study aimed to investigate the potency of the nucleoproteins (NPs) extracted from both snail species on the host immune reactions as an approach to developing a potential vaccine. Methods Three group...

A 3-month experiment was designed to investigate the effects of different stocking densities on growth, stress markers, intestinal digestive enzymes, hepatic antioxidant biomarkers, serum immunity, and survivability of striped catfish, Pangasianodon hypophthalmus . The relationship between fish stocking densities and water quality parameters was also assessed. Healthy fish ( n = 1260 individuals, 17.52 ± 0.20 g) were raised in...