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Mixed effect estimation in deep compartment models: Variational methods outperform first-order approximationsNARA Subscribed
This work focusses on extending the deep compartment model (DCM) framework to the estimation of mixed-effects. By introducing random effects, model predictions can be personalized based on drug measurements, enabling the testing of different treatment schedules on an individual basis. The performance of classical first-order (FO and FOCE) and machine learning based variational inference (VI) algorithms were compared in a simul...
Tide–surge interaction plays a substantial role in determining the characteristics of coastal water levels over shallow regions. We study the tide–surge interaction observed at seven tide gauges along Singapore and the east coast of Peninsular Malaysia, focusing on the timing of extreme non-tidal residuals relative to tidal high water. We propose a modified statistical framework using a no-tide–surge interaction (no-TSI) null...
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach. Our previous evaluation of FDA-approved drugs for their antileukemic activity...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
The diurnal cycle of marine cloud feedback in climate modelsNARA Subscribed
Water resources management in the Aral Basin: a river basin management model for the Syr DaryaNARA Subscribed
The Aral Sea environmental crisis has been created by poor water management in the river basins of the Amu Darya and Syr Darya. Nearly all the flow is abstracted for ailing irrigation schemes in the upper and middle basins, for massive river basin transfer schemes, or is lost to evaporation and seepage from reservoirs and canals. The only solution to the crisis in the lower deltas is to allow more water to flow to them. The pa...
Sexuality in mucoralesNARA Subscribed
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