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Use of translational fusions to express functional Klebsiella oxytoca dinitrogenase reductase in plant mitochondriaNARA Subscribed
Engineering crop plants with the biological nitrogen fixation pathway is a longstanding goal of modern agriculture. Dinitrogenase reductase (NifH) is a critical component of the biological nitrogen fixation pathway, with multiple roles in metal cofactor assembly and catalysis. This enzyme must be folded correctly as a soluble homodimer and loaded with the [4Fe-4S] metallocluster for function. Previous studies have found that K...
Metabarcoding Chironomid Pupal Exuviae Enables Scalable Biomonitoring With High Comparability to MorphotaxonomyNARA Subscribed
Conventional morphotaxonomy‐based biomonitoring requires modernization to enable timely assessments in the face of an accelerating freshwater biodiversity crisis. The Chironomid Pupal Exuviae Technique (CPET) is an established biomonitoring approach with considerable potential for integration with molecular methods, as the shed pupal skins of emerging adults provide a source of DNA. We tested the performance of DNA metabarcodi...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Medicinal cannabis use is increasing worldwide, yet its impacts on driving safety in frequent users are not clearly understood. A more comprehensive understanding of the effects of THC on driving behaviour in frequent users is needed to guide drug driving policy and evidence-based advice for medicinal cannabis consumers. This study investigated the acute effects of orally ingested THC oil on medicinal cannabis users’: (a) haza...
Bakanae disease of rice has emerged as a major threat in the rice‐growingregions of Eastern and Northeastern India. Under field conditions, Fusarium species associated with bakanae disease of rice exhibit a significant degree of variability. Characterizing the pathogen and its isolates is crucial for understanding this variability. This study aimed to assess the genetic diversity and virulence patterns among 88 Fusarium isolat...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...