Extreme weather conditions can cause significant damage to transport infrastructure, including railways, and disrupt its services. In this context, rainfall-induced landslides have been extensively studied with respect to failure probability; however, predicting the probability of damage to railway infrastructure remains challenging due to inadequate documentation of historical damage records from past extreme events. To addre...

Purpose Understanding how spinal orientation affects injury outcome is essential to understand lumbar injury biomechanics associated with high-rate vertical loading. Methods Whole-column human lumbar spines (T12–L5) were dynamically loaded using a drop tower to simulate peak axial forces associated with high-speed aircraft ejections and helicopter crashes. Spines were allowed to maintain natural lordotic curvature for loading,...

Antisense oligonucleotide (ASO) therapeutics present new opportunities for treating challenging-to-treat diseases. Prediction of concentration–time course in systemic circulation and tissues within the context of large molecule physiologically based pharmacokinetic (PBPK) modelling has proven to be useful in animal-to-human extrapolation and first-in-human dose selection. A human PBPK model was developed and verified using bep...

Objective This study investigated how cumulative environmental exposures influence offspring behaviour and inflammation-related molecular signatures in the brain and peripheral immune system. Methods A novel "triple-hit" mouse model was developed using C57Bl/6JAusB mice (N = 70), combining preconceptual social stress, antenatal high-fat diet, and a postnatal immune challenge (poly(I:C), 10 mg/kg). At 12 weeks, offspring underw...

Seaweeds are acknowledged for their potential as biofertilizers and biostimulants, contributing to enhanced growth and yield of various crops globally due to their appropriate amount of macro- and microelements, plant growth regulators, and their richness in bioactive compounds. In the current study, the seaweeds Ulva lactuca , Ulva intestinalis , Corallina officinalis , Ellisolandia elongata , Jania rubens , Colpomenia sinuos...

Abiotic stresses are the most major limitation to crop production, causing yield losses up to 50%, and consider the major challenges for production of crops. Thus, an experiment was conducted to determine how sugar beet would respond to soil application of K-humate rates and foliar application of biostimulants under salt stress. Split-plot design in three replicates was used in both seasons, where K-humate rates fertigation (c...

The West Kalabsha (WKAL) area is a western extreme exploratory area of the Faghur Basin in the Western Desert of Egypt. The study of four wells (WKAL; A-1 X, K-1 X, P-1X, and C-1 X), interpreted with twenty seismic lines, shows that the area is dissected by a series of normal faults with an irregular, E–W strike direction. The general trend of the throw is toward the south–southeast. The most prospective area for hydrocarbon (...