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Timing of water limitation moderates drought hardiness traits of western larch (Larix occidentalis) seedlingsNARA Subscribed
Water limitation during tree seedling cultivation can promote traits that improve drought hardiness. Nurseries apply water limitation mostly during a brief developmental window of seedling growth, which may restrict the range of useful traits achievable through water limitation if phenotypic responses differ across ontogeny. We characterized the diversity of western larch ( Larix occidentalis (Nutt.)) seedling traits produced...
Early-pregnancy exposure to air pollution and stillbirth in São Paulo, Brazil – results from the FetRisks case-control studyNARA Subscribed
Stillbirth remains a major public health concern, particularly in urban settings with persistent air pollution, while evidence remains limited in middle-income countries. This study aims to examine the association between prenatal exposure to fine particulate matter (PM2.5) PM2.5 and stillbirth in São Paulo, Brazil. Case-control study including 348 antepartum stillbirths and 419 live births recruited from 14 public hospitals....
Submaximal walking increases MicroRNA-126 and angiogenic markers in men and women with peripheral arterial diseaseNARA Subscribed
Purpose Vascular dysfunction is a pathophysiological mechanism in peripheral artery disease (PAD). PAD patients exhibit reduced circulating expression of microRNA-126 (c-miRNA-126) and VEGF. Submaximal walking (SW) is recommended in PAD because it increases walking capacity, partially by improving vascular regulation, which can be observed after a walking session. Nevertheless, previous studies were conducted with maximal walk...
Three Decades of Silviculture in Northern Rocky Mountain Forests, USA: Trends, Practices, and OutcomesNARA Subscribed
The Northern Rocky Mountains region includes 42 million acres of forest land which is diverse in landownership, management objectives, tree species, site productivities, disturbance regimes, and silvicultural practices resulting in a mosaic landscape. Substantial changes in landownership, management objectives, markets, policy, forest conditions, and silvicultural practices have occurred over the last thirty years. This review...
Decades of evidence suggests that the relationship between landscape diversity and ecosystem productivity is positive, nonlinear, and saturating—with remarkable consistency across organisms and conditions. Despite this consensus, evidence of the impact of landscape diversity on agricultural productivity remains mixed. We use mixture modeling to systematically examine consistency in the relationship between landscape diversity...
Climate‐driven range expansions of individual species are well‐documented, but corresponding community shifts are not. This lack of widespread community change may indicate communities can resist wholesale change with the arrival of new species. In the northern Gulf of Mexico, climate change is driving the expansion of black mangroves ( Avicennia germinans ) into areas traditionally dominated by smooth cordgrass ( Spartina alt...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Acute Copper Toxicity: Succimer Makes you Less BlueNARA Subscribed
Introduction Acute copper toxicity is a rare occurrence, and management guidelines are not based on robust evidence. Treatment recommendations are often extrapolated from those of chronic copper intoxication and the management of Wilson’s disease. Although D-penicillamine, EDTA, and dimercaprol have varying success, we describe the use of chelation with succimer monotherapy in a patient with acute copper salt ingestion with su...
Species diversity and competition influence nitrogen resorption efficiency in mixed hardwood plantationsNARA Subscribed
Nutrient dynamics substantially influences forest productivity, yet the influence of competition on these processes in forests is not well understood. Nitrogen is an important limiting nutrient for tree growth, but how canopy nitrogen dynamics are influenced by tree diversity and competition is unclear. Nitrogen-use efficiency is one mechanism suggested to support niche complementarity, promoting increased productivity as dive...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Resolving Heterogeneity in the Diagnosis of Alzheimer’s Disease and its Progression Using Multimodal DataNARA Subscribed
Alzheimer’s disease (AD) is a complex and diverse illness that makes early detection extremely difficult. Most existing research utilizes data to identify biomarkers and more homogeneous subgroups to improve the detection, prediction of progression, and prognosis of AD. However, AD still suffers from a lack of appropriate biomarkers for early symptom detection and blurred boundaries between different subgroups. Here, an unsupe...