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Collection, handling and care of cephalopod eggsNARA Subscribed
Research on cephalopod early ontogeny has significantly advanced in recent decades, including embryo organogenesis and neurogenesis and early behavioural adaptations, particularly in commercially important and coastal species. Within this context, here we compiled current knowledge on the collection, handling and care under experimental conditions and monitoring in the field of cephalopod eggs and egg masses. It covers field o...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The proportion of individuals that are found to have empty stomachs during a survey of a predator population's diet has been used as an indicator of the average individual's state of energy balance and of the degree to which its feeding rate (i.e., its functional response) is saturated with respect to prey availability. As such, the proportion of empty stomachs provides insights into the effects of prey on predators and vice v...
Measurement Error and Methodologic Issues in Analyses of the Proportion of Variance Explained in CognitionNARA Subscribed
Existing studies examining the predictive ability of biomarkers for cognitive outcomes do not account for variance due to measurement error, which could lead to under-estimates of the proportion of variance explained. We used data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) ( N = 1084) to estimate the proportion of variance explained by Alzheimer’s disease (AD) imaging biomarkers in four cognitive outcomes: mem...
Grassland soils managed with livestock grazing can act as sources and sinks for methane (CH 4 ) and nitrous oxide (N 2 O), but, in aggregate, are typically a source of N 2 O and a sink for CH 4 . Previously, we observed higher N 2 O losses from fresh patches of urine and manure in shortgrass steppe compared to controls receiving no excreta inputs while CH 4 was a short-term source from manure patches but remained a sink with u...
The Pragmatic Sceptic: A Practical Approach for Integrating Environmental DNA Into Marine Stock Assessment and Fisheries ManagementNARA Subscribed
The ‘omics revolution’ has advanced scientific understanding of marine ecosystems and led to a rapid increase in data that can inform species' population structure, distribution, and abundance. Of the 'omics data types, environmental DNA (eDNA) may present the most cost‐effective opportunity for developing quantitative estimates of abundance trends, a key input for stock assessment models. However, eDNA has yet to be widely ad...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Divergent Population Structure in Five Common Rockfish Species of Puget Sound, WA Suggests the Need for Species‐Specific ManagementNARA Subscribed
Quantifying connectivity between endangered or threatened marine populations is critical information for management and conservation, especially where abundance and productivity differ among such populations. Spatial patterns of such connectivity depend not only on extrinsic factors such as oceanography and bathymetry but also on intrinsic species‐specific factors such as life history, demography and the location of glacial re...
Motivation Terrestrial predators play key roles in cycling nutrients, as well as limiting prey populations, and shaping the behaviour of their prey. Prehistoric, historic and ongoing declines of the world's predators have reshaped terrestrial ecosystems and are a topic of conservation concern. However, the availability of ecologically relevant predator functional traits is limited, hampering efforts to understand macroecologic...
Impact of Exercise Heat Acclimation on Performance in Hot, Cool and Hypoxic ConditionsNARA Subscribed
Purpose The aim of this study was to confirm the impact of heat acclimation on aerobic performance in hot conditions and elucidate the transfer of heat adaptations to cool and hypoxic environments. Methods Ten males (VO 2peak : 4.50 ± 0.50 L/min) completed two three-week interventions consisting of heat acclimation (HA: 36°C and 59% RH) and temperate training (TEMP: 18°C and 60% RH) in a counter-balanced crossover design. Trai...
Parascaris spp. eggs shedding patterns in juvenile horsesNARA Subscribed