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The combined effects of CuSO4 and NaSH in pyrite activationNARA Subscribed
Mating systems shape the population dynamics of species, influencing attributes such as effective population size and population persistence. Traditionally, genetic analysis of mating systems includes the genotyping of putative parents to determine parentage. However, for cryptic or migratory species, and those with large populations, comprehensive sampling of adults is often not feasible. One underutilised alternative is to r...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Sexual dimorphism includes external morphological differences between sexes. In caridean shrimps, the established characteristics for sexing individuals are the presence or absence of an appendix masculina in males and the position of the male/female gonopores. Shrimps of the genus Synalpheus are an exception because males lack appendices masculinae on the second pleopods. Synalpheus males can be distinguished from females by...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Brain Delivery of a Kv1.3-Blocking Peptide is not Enhanced by Conjugation to Blood–Brain Barrier Shuttle PeptidesNARA Subscribed
Purpose The voltage-gated potassium channel K V 1.3 is upregulated on pro-inflammatory microglia, and its blockade is effective in reducing neuroinflammation in vitro and in vivo. The most potent and selective K V 1.3 blockers identified to date are disulfide-rich, venom-derived peptides, which are largely excluded from the brain by the blood–brain barrier (BBB). As BBB shuttle peptides have been reported to promote receptor-m...
Human invariant natural killer T (iNKT) cells are a conserved population of innate-like T cells that are activated by glycolipid antigens. In addition to their well-known role in anti-tumor function, iNKT cells are also involved in regulating and maintaining hematopoiesis in the bone marrow. Here, we present the reprogramming of human CD4 + Vα24 + Vβ11 + iNKT cells into induced pluripotent stem cells (iNKT-iPSCs) and describe...
Values of protected area landscapes shape the behaviors of subsistence users in Interior AlaskaNARA Subscribed
Diverse values expressed by people living around protected areas provide insight into shared reasons why agreements and tensions may exist yet are underrepresented in research with subsistence users. We administered a mixed-mode survey to residents living near Denali National Park and Preserve and Denali State Park in Interior Alaska, USA, to understand how values placed on landscapes by multiple interest groups could lead to...
Atmospheric Freezing Level Height ChangesNARA Subscribed
Previous studies have found that the freezing level height (FLH) increases under the background of global warming, with negative effects on the global cryosphere, especially over mountain regions. In this study, with observation and model simulations, global FLH changes are updated to 2023. It is found that there are relatively smaller positive FLH trends and changes over the Tropics, but higher FLH changes over the extra‐Trop...