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The aetiology of frailty remains unknown. It has been hypothesised that individual differences in epigenetic mechanisms, particularly DNA methylation (DNAm), may help to explain why some individuals become frail while others do not. Relating epigenetic measures to transitions in age-related frailty in individual patients requires longitudinal studies over many years. To overcome this barrier, we study associations between DNAm...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Pollution‐Driven Selection in a Non‐Biting Midge: Genome‐Wide Responses to Bacillus thuringiensis israelensis and CopperNARA Subscribed
Riparian ecosystems are vital interfaces between aquatic and terrestrial environments but are increasingly impacted by anthropogenic pollution. In these systems, merolimnic insects serve as crucial ecological links, occupying aquatic habitats as larvae and terrestrial environments as adults, thus being an essential food source in both. Consequently, pollutant exposure during the aquatic larval stage can have cascading effects...
In 2023, more than half of olive harvests ( Olea europaea ) across Spain, Greece, and Türkiye were lost to drought. The same year late freeze destroyed 90% of the peach crop ( Prunus persica ) on the Georgia Piedmont and the apple crop ( Malus domestica ) in central New York, Vermont, and southern Quebec. Climate extremes now rank with the costliest threats to agriculture, but their role in forest recovery from diebacks that a...
Local Adaptation and Osmoregulatory Mechanisms of the Copepod Acartia tonsa Under Low Salinity StressNARA Subscribed
Salinity—an essential factor shaping marine species distributions—is rapidly shifting due to global change, yet the mechanisms of salinity tolerance and adaptation remain poorly understood. We investigated local adaptation in the calanoid copepod Acartia tonsa , a broadly distributed marine species that thrives in the brackish Baltic Sea. Using a common‐garden design, we compared physiological and transcriptomic responses to l...
Although cratons owe their longevity to thick, depleted and consequently buoyant sub-continental lithospheric mantle, their extents are commonly indicated by the known distribution of crustal rocks. However, the limits of a mapped cratonic area often do not match the seismically imaged thick sub-continental lithospheric mantle roots. New mantle xenolith petrology and geochemistry, combined with continental scale geophysical da...
Climate change and local pressures are eroding the health and performance of many watersheds and their freshwater ecosystems, pushing these complex social‐ecological systems to the boundaries of their safe operating space. Here, we offer a synthetic perspective on the downscaled application of the safe operating space concept to inform the stewardship of watersheds in this time of rapid climate change, with particular focus on...
Thierry B.R. Chopin (1959–2024) – Innovator of Modern IMTANARA Subscribed
A comparison of environmental DNA sampling strategies for detecting anuran populations in wetlandsNARA Subscribed
Sensitive and efficient monitoring of species’ distributions is crucial for understanding biodiversity and conserving species. Environmental DNA (eDNA) metabarcoding enables rapid detection of biological communities and its use is increasing in freshwater ecosystems. However, variations in eDNA sampling method may influence results. We compared anuran species richness estimates derived from two eDNA filtration strategies: (i)...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Remotely Sensed Fire Heterogeneity and Biomass Recovery Predicts Empirical Biodiversity ResponsesNARA Subscribed
Aim To compare field‐based evidence of plant and animal responses to fire with remotely sensed signals of fire heterogeneity and post‐fire biomass recovery. Location South‐eastern Australia; New South Wales. Time Period 2019–2022. Major Taxa Studied A total of 982 species of plants and animals, in eight taxonomic groups: amphibians, birds, fish, insects, mammals, molluscs, plants and reptiles. Methods We collated 545,223 plant...
A spatially explicit assessment of factors shaping attitudes toward African elephant conservationNARA Subscribed
Conservation plans that explicitly account for the social landscape where people and wildlife co‐occur can yield more effective and equitable conservation practices and outcomes. Yet, social data remain underutilized, often because social data are treated as aspatial or are analyzed with approaches that do not quantify uncertainty or address bias in self‐reported data. We conducted a survey (questionnaires) of 177 households i...