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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Hair cortisol concentrations as marker of chronic stress in wild roe deer (Capreolus capreolus)NARA Subscribed
The stress response to different stimuli involves the release of mediators, with cortisol being the principal, aimed to induce physiological, metabolic, and behavioral changes for restoring allostatic balance. However, prolonged or excessive cortisol secretion may impair welfare by altering immunity, growth, and reproduction. Cortisol concentrations or its metabolites can be measured in several biological matrices, and may acc...
A geological and geophysical database for the assessment of offshore freshened groundwater resourcesNARA Subscribed
Fresh groundwater resources in coastal regions are vital for modern society, but are under considerable pressure due to population growth, seasonal peaks in demand, pollution and climate change. In recent years, interest in offshore freshened groundwater (OFG) has surged, as potential resource for addressing these challenges. Recent studies have documented OFG occurrences on many continental margins and islands, with global vo...
Widespread Shrubification on European Mountain SummitsNARA Subscribed
Shrubs are expanding across the cold ecosystems of our planet with potentially profound consequences for their biodiversity and functioning. However, evidence is still strongly biased towards the Arctic tundra, while a large‐scale assessment of shrub expansion in alpine areas above the elevational treeline is missing so far. Here we quantified shrub cover changes over the past two decades in 576 permanent plots of 1 m 2 spread...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Decreased Complex I Activity in Blood lymphocytes Correlates with Idiopathic Pulmonary Fibrosis SeverityNARA Subscribed
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease linked to aging. Mitochondrial dysfunction in circulating T cells, often caused by disruption of mitochondrial DNA (mtDNA), may play a role in age-related conditions like IPF. In our previous study, we found high mtDNA mutational loads in blood lymphocytes from IPF patients, especially in regions critical for mtDNA expression. Since Complex I of the...