There are challenges that require collaboration among researchers to ensure that tobacco harm reduction strategies are evidence-based. A key challenge is evaluating the safety of flavors in e-cigarettes. Many flavorings are deemed “generally recognized as safe” (GRAS) for ingestion, but this does not guarantee their safety when inhaled. The Replica international research group is dedicated to the replication of studies on toba...

Social housing is desirable for the health and well-being of laboratory mice, as social interactions with conspecifics influence both behavioral and physiological outcomes. Although group housing benefits social species, it can introduce variability in mortality outcomes, and raise welfare concerns, particularly with the emergence of aggression or fluctuating cage densities. Despite this, few studies have evaluated how changes...

Extreme precipitation shows non-stationarity, meaning that its distribution can change with time or other large-scale variables. For a classical frequency-intensity analysis this effect is often neglected. Here, we propose a model including the influence of North Atlantic Oscillation, time, surface temperature and a blocking index. The model features flexibility to use annual maxima as well as seasonal maxima to be fitted in a...

The exponential rise of information available means we can now, in theory, access knowledge on almost any question we ask. However, as the amount of unverified information increases, so too does the challenge in deciding which information to trust. Farmers, when learning about agricultural innovations, have historically relied on in-person advice from traditional ‘experts’, such as agricultural advisers, to inform farm managem...

Over the last 20 years, new concepts have emerged into understanding the processes that lead to build up to large silicic explosive eruptions based on integration of geophysical, geochemical, petrological, geochronological and dynamical modelling. Silicic melts are generated within magma systems extending throughout the crust by segregation from mushy zones. Segregated melt layers become unstable and can assemble into ephemera...