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Tree Regeneration After Unprecedented Forest Disturbances in Central Europe Is Robust but Maladapted to Future Climate ChangeNARA Subscribed
Central Europe has been a hotspot of forest disturbance during 2018–2020, with large pulses of tree mortality from drought and bark beetles. Post‐disturbance recovery is crucial for forest resilience and the continued provision of ecosystem services. We surveyed 849 plots in disturbance hotspots across 10 Central European countries to assess the state of early (3–5 years) post‐disturbance tree regeneration. Our specific object...
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by systemic oxidative stress and inflammation that extends beyond the pulmonary vasculature to the musculoskeletal system. Combined exercise training (ET), incorporating aerobic and resistance components, is a promising non-pharmacological intervention, but its effects on musculoskeletal oxidative stress and inflammation remain unclear. To evaluate th...
Background: Priming strategies that improve the functionality of MSCs may be required to address issues limiting successful clinical translation of MSC therapies. For conditions requiring high trophic support such as brain and spinal cord injuries, priming MSCs to produce higher levels of trophic factors may be instrumental to facilitate translation of current MSC therapies. We developed and tested a novel molecular priming pa...
Assessment of genetic diversity in a locally endangered tern species suggests population connection instead of isolationNARA Subscribed
Many bird populations are declining globally, with migratory sea- and waterbirds among the most threatened groups. Increased isolation between populations, due to habitat loss leading to limited connectivity and reduced gene flow, may accelerate population declines or even cause local extinctions. To address this threat and inform conservation efforts, assessment of the genetic diversity of endangered populations is required....
Unveiling Swelling and Erosion Dynamics: Early Development Screening of Mirabegron Extended Release TabletsNARA Subscribed
Although the development of extended release (ER) matrices has been extensively investigated, understanding the most appropriate mechanism of drug release to achieve the desired release remains a cost- and time-consuming challenge in the early stages of formulation development. This study aimed to investigate the early stage of developing ER hydrophilic matrix tablets containing mirabegron as a model drug, focusing on the effe...
Dominance and rarity in tree communities across the globe: Patterns, predictors and threatsNARA Subscribed
Aim Ecological and anthropogenic factors shift the abundances of dominant and rare tree species within local forest communities, thus affecting species composition and ecosystem functioning. To inform forest and conservation management it is important to understand the drivers of dominance and rarity in local tree communities. We answer the following research questions: (1) What are the patterns of dominance and rarity in tree...