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Deviations from additivity in APOE4-mediated late-onset Alzheimer’s disease risk across races and ethnicitiesNARA Subscribed
APOE ’s ε4 haplotype ( APOE4 ) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4 ’s effect is critical to understanding LOAD. This is especially important as APOE4 odds ratios (OR) vary across racial and ethnic (R/E) groups. We analyzed the APOE4 -LOAD association in 3,196 East Asian, 31,105 non-Hispanic White (White), 1,646 Hispanic and Latino (Hispanic), and 6,068...
Comparative spore wall architecture and development across hornwort diversity and across timeNARA Subscribed
Hornworts are a small group of plants exclusively characterized by asynchronous sporogenesis and a sporangium that grows from its base. Among the most widely used and reliable features that delineate hornwort taxa are those related to spores, especially shape, color and spore wall ornamentation. The present study provides comparative data on the development and microanatomy of spores from all genera, representing the range of...
Climate Attribution in Fishery Stock Assessment: Case Studies From the Northeast U.S. Groundfish StocksNARA Subscribed
Climate change poses an unprecedented risk to fisheries ecosystems and economies globally. Ocean warming has led to observed geographic shifts and changes in the productivity of fish stocks. Due to the rapid pace of change in many of the world's oceans, there is a critical need to develop and apply scientific knowledge and tools that can help account for non‐stationarity and integrate climate and ecosystem drivers into fishery...
Understanding the spatio-temporal dynamics of volumes of construction materials is becoming crucial for environmental sustainability and achieving long-term development goals. Whilst direct data collection is always the preferable option it is not always practical. This study presents a new methodology for quantifying national-scale material stocks in Malaysia using high-resolution Earth Observation (EO) data. The study includ...
Associations between patterns of brain connectivity and brain structural features have transdiagnostic relevance to psychopathology. There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present study examines structure–function relationships—specifically, the relation of hippocampal volume with patterns of temporoparietal effective connectivity—in youth...