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Timing of exposure impacts how organophosphorus pesticides affect the developing brain in the planarian Dugesia japonicaNARA Subscribed
Exposure to organophosphorus pesticides (OPs) during pregnancy has been suggested to cause adverse outcomes on neural development of the fetus but the mechanisms underlying developmental neurotoxicity of OPs remain unclear. While OPs share acetylcholinesterase (AChE) as the primary molecular target, different OPs have been shown to induce different effects in laboratory studies. Previously, we found that OPs differentially aff...
Conservation implications of low contemporary connectivity along the Mid‐Atlantic Ridge in hydrothermal vent gastropodsNARA Subscribed
Polymetallic sulfide deposits produced at hydrothermal vent fields are targets for mining exploitation along the Mid‐Atlantic Ridge, threatening the functioning and resilience of vent ecosystems that provide multiple ecosystem services. Knowledge about connectivity between vents will inform conservation practices. The present‐day genetic structure and demographic history of the two vent‐dwelling gastropod species, Lepetodrilus...
Hydro-mechanical properties of compacted chalkNARA Subscribed
Historically, chalk has always been widely used as a building material in public works projects such as dams, dikes and pavements. Given its characteristics as an evolving rock, its properties and behavior are well mastered by its users, not always with rational but rather empirical methods. This study examines the hydro-mechanical behavior of chalk correlating these findings with its physical and microstructural characteristi...
The aetiology of frailty remains unknown. It has been hypothesised that individual differences in epigenetic mechanisms, particularly DNA methylation (DNAm), may help to explain why some individuals become frail while others do not. Relating epigenetic measures to transitions in age-related frailty in individual patients requires longitudinal studies over many years. To overcome this barrier, we study associations between DNAm...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Macro-level determinants of nature connectedness: An exploratory analysis of 61 countriesNARA Subscribed
Nature connectedness is increasingly recognised as a causal issue in environmental crises and a powerful strategy for transformative change. However, little is known about how it varies across countries and the macro-level factors that influence the human–nature relationship at a societal level. Using a large dataset ( N = 56 968) from a diverse set of 61 countries, this study explored how both objective country-level indicato...
Global Molecular Taxonomy, Phylogeny and Biogeography of the Clam Genus Corbicula (Bivalvia: Cyrenidae)NARA Subscribed
The Corbicula clams (Bivalvia: Cyrenidae) are an ecologically significant and widespread group of fresh‐ and brackish‐water molluscs, playing a keystone role in aquatic ecosystems. Some species of this genus are subglobal invaders. The taxonomy of Corbicula remains very confusing, which hinders both fundamental and applied research on this genus. A comprehensive revision of the taxonomic structure of this group has been lackin...