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Endoplasmic reticulum stress induced autophagy alters cellular processing of cationic lipid delivered siRNAsNARA Subscribed
siRNA therapeutics have achieved increased clinical success in the past decade. To achieve a therapeutic effect, siRNAs must enter the cytoplasm of the target cells. Thus, their function typically relies on proper endocytosis and trafficking. Endoplasmic reticulum (ER) stress is associated with diseases that are being studied for treatment with siRNAs (cancer, amyloids, mutations, etc.) and common comorbidities (obesity, smoki...
Most vaccines require refrigerated transport and storage, which is costly, challenging in low-resource settings, and results in the loss of up to 50% of vaccines globally due to “cold-chain” failures. Here, tetanus toxoid vaccine (TT) was thermostabilized by encapsulation within a metal-organic framework (MOF), zeolitic imidazolate framework-8 (TT@ZIF-8). Its physicochemical properties were characterized by X-ray diffraction,...
An Outbreak of Synthetic Cannabinoid-Adulterated Tianeptine Products in New Jersey – Case SeriesNARA Subscribed
Background Tianeptine, an atypical antidepressant not approved in the United States, is readily purchased from unregulated markets such as the internet and gas stations. We became aware of a cluster of 34 patients in New Jersey who became ill following ingestion of the tianeptine containing-product Neptune’s Fix, the rate of which (4.6 cases per month) far exceeded the background rate for this substance of 0.5 cases per year....
The Peace of Mind Program is an evidence-based intervention to improve mammography appointment adherence in underserved women. The aim of this study was to assess effectiveness of the intervention and implementation of the intervention in safety net clinics. The intervention was implemented through a non-randomized stepped wedge cluster hybrid study design with 19 Federally Qualified Health Centers and charity care clinics wit...
Tissue loss disease outbreak significantly alters the Southeast Florida stony coral assemblageOA Marine
A stony coral tissue loss disease (SCTLD) outbreak, first widely reported in 2014 in the Southeast Florida Ecosystem Conservation Area (Coral ECA), has continued to impact stony coral communities for more than seven years. Here, we utilize long-term (2012-2020) annual monitoring data from the Southeast Florida Reef Evaluation and Monitoring Project (SECREMP) to assess the impact of the SCTLD outbreak on the stony coral assembl...
Transcriptomic analysis of preovipositional embryonic arrest in a nonsquamate reptile (Chelonia mydas)NARA Subscribed
After gastrulation, oviductal hypoxia maintains turtle embryos in an arrested state prior to oviposition. Subsequent exposure to atmospheric oxygen upon oviposition initiates recommencement of embryonic development. Arrest can be artificially extended for several days after oviposition by incubation of the egg under hypoxic conditions, with development recommencing in an apparently normal fashion after subsequent exposure to n...
Laboratory Simulation of Groundwater Along Uranium-Mining-Affected Flow Paths Near the Grand Canyon, Arizona, USANARA Subscribed
Mining of volumetrically small, but relatively enriched (average 0.6% U 3 O 8 ) breccia pipe uranium (BPU) deposits near the Grand Canyon, Arizona, USA has the potential to affect groundwater and springs in the area. Such deposits also contain base metal sulfides that can oxidize to generate acid mine drainage and release trace metals. In this study, sequential batch experiments were conducted to simulate the geochemistry of l...
Long‐term monitoring indicates shifting fall migration timing in monarch butterflies ( Danaus plexippus )NARA Subscribed
Eastern North American monarch butterflies ( Danaus plexippus) embark on a yearly migration between summer breeding grounds in the northern United States and southern Canada and overwintering sites in central Mexico, traveling up to 4300 km. This annual multi‐generational migration cycle, like many seasonal natural phenomena, may be impacted by recent changes in climate and habitat. We investigated long‐term trends in monarch...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...