Human activities can impact the genetic diversity of populations, making them more vulnerable to extinction. Rare species are at an increased risk of negative genetic consequences of human activities, but understanding genetic diversity in rare species requires comparison to more common congeners. Hybridization, a common phenomenon in plants, can provide genetic rescue of genetically depauperate populations or put rare species...

Tissue-engineered models of skin have evolved over the past 50 years, have successfully been translated to clinical use and continue to be improved using new technologies. However, very few of these constructs incorporate a hypodermal component. The hypodermis is critical to skin homeostasis, skin function and many skin diseases, but our understanding of the hypodermis is limited in comparison to our knowledge of the epidermis...

Slag analyses from archaeological iron smelting sites are common. Rigorous analyses of iron and slag from successful experimental smelting, however, are still rare. Furthermore, thorough analyses from a series of smelts, and of the slag produced in different phases of the smelt, are exceedingly rare. The present study investigates the effect of an iron smelter’s decision-making and skills on the products of the smelting proces...

Recent changes in the pharmaceutical industry have led to significant paradigm shifts in the pharmaceutical quality environment. Globalization of the pharmaceutical industry, increasingly rapid development of novel therapies, and adoption of new manufacturing techniques have presented numerous challenges for the established regulatory framework and quality environment and are impacting the approaches utilized to ensure the qua...