S. de Groot results 55
· Newest (Page 1/3, per page 25)
Author: S. de Groot ×Clear All Filters
Search Results
Predatory mites as potential biological control agents for tomato russet mite and powdery mildew on tomatoNARA Subscribed
Tomato plants are attacked by numerous pests and diseases, including the tomato russet mite Aculops lycopersici and powdery mildew, Oidium neolycopersici . Natural enemies of tomato pests are often hindered by the tomato trichomes, while russet mites live under and among these leaf hairs and are therefore protected from these enemies. To find natural enemies that are adapted to tomato and its trichomes, we collected a predator...
Preclinical Models of Cardiac Disease: A Comprehensive Overview for Clinical ScientistsNARA Subscribed
For recent decades, cardiac diseases have been the leading cause of death and morbidity worldwide. Despite significant achievements in their management, profound understanding of disease progression is limited. The lack of biologically relevant and robust preclinical disease models that truly grasp the molecular underpinnings of cardiac disease and its pathophysiology attributes to this stagnation, as well as the insufficiency...
Population genomics of the muskox' resilience in the near absence of genetic variationNARA Subscribed
Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox ( Ovibos moschatus ), an Ice Age relict that was at t...
Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic TherapeuticsNARA Subscribed
The identification and removal of host cell proteins (HCPs) from biologic products is a critical step in drug development. Despite recent improvements to purification processes, biologics such as monoclonal antibodies, enzyme replacement therapies, and vaccines that are manufactured in a range of cell lines and purified using diverse processes may contain HCP impurities, making it necessary for developers to identify and quant...
Does conduction heterogeneity determine the supervulnerable period after atrial fibrillation?NARA Subscribed
Atrial fibrillation (AF) resumes within 90 s in 27% of patients after sinus rhythm (SR) restoration. The aim of this study is to compare conduction heterogeneity during the supervulnerable period immediately after electrical cardioversion (ECV) with long-term SR in patients with AF. Epicardial mapping of both atria was performed during SR and premature atrial extrasystoles in patients in the ECV ( N = 17, age: 73 ± 7 years) an...
Subsidy accessibility drives asymmetric food web responsesNARA Subscribed
Global change is fundamentally altering flows of natural and anthropogenic subsidies across space and time. After a pointed call for research on subsidies in the 1990s, an industry of empirical work has documented the ubiquitous role subsidies play in ecosystem structure, stability, and function. Here, we argue that physical constraints (e.g., water temperature) and species traits can govern a species' accessibility to resourc...
Evidence for near-source nonlinear propagation of volcano infrasound from Strombolian explosions at Yasur Volcano, VanuatuNARA Subscribed
Volcanic eruption source parameters may be estimated from acoustic pressure recordings dominant at infrasonic frequencies (< 20 Hz), yet uncertainties may be high due in part to poorly understood propagation dynamics. Linear acoustic propagation of volcano infrasound is commonly assumed, but nonlinear processes such as wave steepening may distort waveforms and obscure the sourcing process in recorded waveforms. Here we use a p...
Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this service, develop predictions, and...
Avoidance of the Plant Hormone Cis-Jasmone by Aedes aegypti Depends On Mosquito Age in Both Plant and Human Odor BackgroundsNARA Subscribed
Adults of many mosquito species feed on plants to obtain metabolic energy and to enhance reproduction. Mosquitoes primarily rely on olfaction to locate plants and are known to respond to a range of plant volatiles. We studied the olfactory response of the yellow fever mosquito Aedes aegypti to methyl jasmonate (MeJA) and cis -jasmone (CiJA), volatile compounds originating from the octadecanoid signaling pathway that plays a ke...
Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapyNARA Subscribed
Response evaluation for cancer treatment consists primarily of clinical and radiological assessments. In addition, a limited number of serum biomarkers that assess treatment response are available for a small subset of malignancies. Through recent technological innovations, new methods for measuring tumor burden and treatment response are becoming available. By utilization of highly sensitive techniques, tumor-specific mutatio...
Purpose Antidepressants like the serotonin reuptake inhibitors (SRIs) are often used concomitantly with tamoxifen (e.g. for treatment of depression). This may lead to an additional prolongation of the QTc-interval, with an increased risk of cardiac side effects. Therefore we investigated whether there is a drug-drug interaction between tamoxifen and SRIs resulting in a prolonged QTc-interval. Methods Electrocardiograms (ECGs)...