Cardiac diseases are strongly associated with aging and pose a major threat to survival. This study evaluated the cardioprotective effects of oral eugenol and its nano-emulsion (20 mg/kg) in a D-galactose-induced aging model (300 mg/kg, i.p.) in male and female rats over 12 weeks. Particle size and zeta potential analyses confirmed the successful development of a stable, well-dispersed nano-emulsion system. At the end of treat...

The round sardinella (Sardinella aurita Valenciennes, 1847) is a widely distributed migratory pelagic fish inhabiting the Mediterranean Sea and the eastern Atlantic coasts. The species is heavily exploited and represents a valuable resource for global fisheries. In the Mediterranean area, uptakes of round sardinella are particularly high in the Ionian and Levant regions, where landings have shown fluctuating yet significant pe...

The aim of the current study is to identify the possible protective effect of rupatadine (RUP) on ovarian ischemia reperfusion (OIR) in rats. RUP was administered in the presence and absence of OIR. Thirty-two adult Wistar albino female rats were randomly arranged into four groups: Sham, RUP (6 mg/kg/day) for 14 days, OIR and OIR + RUP groups.The results demonstrated that OIR significantly lowered serum anti-mullerian hormone...

T his article is aimed at assessing the anti-fibrotic action of plant-based fabricated cerium oxide nanoparticles (CeO 2 NPs). The Carissa carandas aerial parts methanolic extract was utilized to prepare CeO 2 NPs, where the dispersal of particle size distribution and zeta potential value was 61.9 nm and − 18.94 mV, respectively, verifying the successful synthesis of CeO 2 NPs. In rats, CeO 2 NPs were intravenously injected at...

This research was designed to explore the anti-epileptic action of the ethanolic leaf extract of Lagerstroemia loudonii (LLE) compared to the extract-loaded MβCD-stabilized nanosuspension (MβCD-NS). UPLC–ESI–QTOF –MS/MS analysis of LLE revealed the identification of 57 compounds; phenolics were the major recorded class. Nanosuspensions were prepared and examined; the particle size of the selected physically stable MβCD-NS was...