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Purpose The current study evaluated the cell attachment capability and long-term stability of 5 - fluorouracil (5-FU) loaded alginate-gelatin scaffolds reinforced with zinc-doped hydroxyapatite (Zn-HA). Methods Zn-HA (2% and 6% Zn) was prepared and evaluated for the crystalline nature, chemical structure, and microstructure of hydroxyapatite (HA). Blank and 5-FU loaded alginate-gelatin-Zn-HA scaffolds were prepared and evaluat...
Pyrazole derivatives ameliorate synovial inflammation in collagen-induced arthritis mice model via targeting p38 MAPK and COX-2NARA Subscribed
The type II collagen-induced arthritis (CIA) model and human rheumatoid arthritis exhibit similar characteristics. Both diseases involve the production of inflammatory cytokines and other mediators, triggering an inflammatory cascade linked to bone and cartilage damage. Recently, new pyrazole compounds with various pharmacological activities, including antimicrobial, anticancer, anti-inflammatory, and analgesic agents, have be...
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