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Formulation and Evaluation of Immediate-Release Quetiapine Fumarate Tablets Via Twin-Screw Melt GranulationNARA Subscribed
Purpose This study aimed to develop immediate-release Quetiapine Fumarate (QTF) tablets using twin-screw melt granulation (TSMG), a solvent-free and efficient granulation method, and compare their dissolution profiles with the marketed product. Methods QTF tablets were formulated using TSMG with varying concentrations of Ludiflash ® as a diluent and HPMC as a binder. Granules were prepared using a twin-screw extruder at 150 °C...
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