Cardiac diseases are strongly associated with aging and pose a major threat to survival. This study evaluated the cardioprotective effects of oral eugenol and its nano-emulsion (20 mg/kg) in a D-galactose-induced aging model (300 mg/kg, i.p.) in male and female rats over 12 weeks. Particle size and zeta potential analyses confirmed the successful development of a stable, well-dispersed nano-emulsion system. At the end of treat...

Cercospora leaf spot (CLS), caused by Cercospora beticola , is a severe threat to sugar beet ( Beta vulgaris ) production in Egypt’s Nile Delta and poses resistance and ecological problems to synthetic fungicides. This study investigates Alhagi maurorum (camelthorn), an endemic medicinal shrub of arid regions, and evaluates it as a sustainable plant-sourced biofungicide for integrated CLS management. Following molecular confir...

Ursolic Acid (UA), a naturally occurring pentacyclic triterpene, was isolated from Ochrosia elliptica . Polycystic Ovary Syndrome (PCOS) a prevalent endocrine disorder characterized by hyperandrogenism, insulin resistance, and chronic inflammation. In this study, we investigate the role of UA in alleviating the symptoms of PCOS, focusing on its biochemical, hormonal, and histopathological effects in a rat model. Using adult fe...

Sugar beet ( Beta vulgaris var. saccharum, L.), a primary contributor to the worldwide sugar market, suffers severely from powdery mildew caused by Erysiphe betae , which reduces the photosynthetic efficiency and therewith yields. This study presents molecular docking analysis and randomized complete block design (RCBD) field trials with nutrient foliar sprays to identify disease management strategies. The interaction study in...

Rheumatoid arthritis (RA) is an autoimmune disease primarily manifested by insistent proliferative synovitis, joint degradation, and bone erosions with no targeted therapy yet. Spirulina platensis serves as a treasure house of bioactive compounds with potential significance against different inflammatory ailments. Inspired by the potentiating biological attributes of S. platensis , the current investigation is concerned with d...

Proteus mirabilis is a major bacterium responsible for catheter-associated urinary tract infections (CAUTIs). Urease enzyme has a great role in the pathogenesis of Proteus mirabilis. Using urease, Proteus mirabilis can decompose urea to produce ammonia that increases urine pH and enhances crystal precipitation and crystalline biofilm formation. This leads to catheter blockage and pyelonephritis, respectively. Urease inhibitors...

An attempt was undertaken to comprehend how phenotypic markers, leaf tip necrosis (LTN), and pseudo black chaff (PBC), are associated with pleiotropic resistance genes in wheat ( Triticum spp.). Pleiotropic resistance to stripe rust ( Puccinia striiformis f. sp. tritici ), leaf rust ( P. triticina ), stem rust ( P. graminis f. sp. tritici ) and powdery mildew ( Blumeria graminis f. sp. tritici ) was evaluated in 57 Egyptian sp...

Currently, the world is facing many troubles in crop production and the irrigation water deficit is the most harmful among them. Saving irrigation water is the main target for all countries of the world, especially in arid areas. Field trial was executed aiming to assess the influence of irrigation regimes (100, 80 and 60% of irrigation requirements, IR (IR 100 , IR 80 and IR 60 , respectively), water-absorbent substances (con...

Background Dexamethasone-induced neurotoxicity has been previously reported. However, the molecular mechanisms are still not completely understood. Objectives The current work aimed to investigate the modulatory effects of α- and β-adrenergic receptors on dexamethasone-induced neurotoxicity in rats focused on changes in β-arrestin2 and molecular markers of neural injury in cerebral cortex. Methods Male Wistar rats were subcuta...

Powdery mildew caused by Blumeria graminis f. sp. tritici ( Bgt ), is one of the serious diseases that attack wheat plants during the growing season. The Bgt virulence was screened against 16 Egyptian wheat cultivars and 21 powdery mildew differential lines carrying different ( Pm ) resistance genes in two regions (Kafr-Elsheikh and El-Minya) in Egypt 2021–2022. Broad-spectrum virulence and high diversity were observed at both...

This study was conducted to evaluate the effects of Spirulina platensis in Nile tilapia diets on growth performance, blood hematological and biochemical parameters, immunological status, and intestinal histomorphometry. A total of 228 fish were randomly allocated into four groups with triplicates (19 fish per replicate). The first group was fed the control diet, which contained no Spirulina supplementation. The other three gro...

Doxorubicin (DOX) is an anti-neoplastic therapy, but its use is limited by its deleterious toxic effects including nephrotoxicity and cardiotoxicity. This work aimed at assessing the potential protective effect of Ceratonia siliqua methanol extract (CME) on DOX-induced nephrotoxicity in 5 groups of Wistar rats. Nephrotoxicity was induced experimentally by intraperitoneal (IP) injection of DOX (15 mg/kg). DOX increased serum cr...

Evaluating residual lead (Pb) and cadmium (Cd) levels in food products, especially milk, is critical for product safety and quality. In this purview, the current study aims to determine Pb and Cd concentrations in milk using atomic absorption spectrophotometry and compare their values with international standards. In addition, it aims to remove these metals from milk samples using low-cost, naturally occurring materials, such...