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A task-aligned multimodal machine learning framework for studying working memory dysfunction in Parkinson’s diseaseNARA Subscribed
Cognitive impairment is one of the most functionally debilitating non-motor symptoms in Parkinson's disease (PD). Yet, current diagnostic and clinical practices rely heavily on subjective assessments and burdensome behavioral testing, which lack the temporal resolution to detect subtle deficits. While EEG and pupillometry offer promising non-invasive insights into cognitive processing, more scalable and objective methods are n...
Identification of Age-Associated Upstream Regulators to Promote Neuronal Resilience in HD Patient-Derived NeuronsNARA Subscribed
Aging is a risk factor for neurodegenerative disorders, but the molecular link between neuronal aging and neurodegeneration remains unclear. Huntington’s disease (HD) is an inherited neurodegenerative disorder with adult-onset clinical symptoms. Striatal medium spiny neurons (MSNs) are mainly affected in HD, but how aging contributes to MSN degeneration remains uncertain. Using directly converted MSNs from fibroblasts of HD pa...
Introduction Carbon monoxide (CO) is a leading cause of environmental poisoning in the United States with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and mitochondrial dysfunction. Currently both biomarkers and therapies for CO poisoning are limited and require new approaches. Methods Rats (~ 300 g) were divided into four groups of ten rodents per group (exp...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
World Octopus FisheriesNARA Subscribed
The global abundance of tree palmsNARA Subscribed
Aim Palms are an iconic, diverse and often abundant component of tropical ecosystems that provide many ecosystem services. Being monocots, tree palms are evolutionarily, morphologically and physiologically distinct from other trees, and these differences have important consequences for ecosystem services (e.g., carbon sequestration and storage) and in terms of responses to climate change. We quantified global patterns of tree...
Ventral tegmental area GABA neurons and opiate motivationNARA Subscribed
A freshwater cyanophage whose genome indicates close relationships to photosynthetic marine cyanomyophagesNARA Subscribed
Summary Bacteriophage S‐CRM01 has been isolated from a freshwater strain of Synechococcus and shown to be present in the upper Klamath River valley in northern California and Oregon. The genome of this lytic T4‐like phage has a 178 563 bp circular genetic map with 297 predicted protein‐coding genes and 33 tRNA genes that represent all 20‐amino‐acid specificities. Analyses based on gene sequence and gene content indicate a clos...
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