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Preparing Children for Invasive Medical Cancer Treatment with “My Logbook”: Preliminary Results of a Pilot StudyNARA Subscribed
Pediatric cancer is one of the most burdensome chronic diseases, necessitating a variety of severe medical interventions. As a result, the disease and its treatment cause numerous acute and long-term medical, psychological, and socioeconomic strains for young patients and their families. Therefore, psychosocial care using evidence-based interventions (EBIs) before, during, and after medical treatments is essential to ensure th...
Factors Influencing Health-Related Quality of Life of Patients with Spinocerebellar AtaxiaNARA Subscribed
Background Little is known about the progression of health-related quality of life (HRQoL) and predicting factors in spinocerebellar ataxia (SCA). Such knowledge is crucial to identify modifiable factors promoting everyday life with SCA and attenuating HRQoL decline. Objectives This study is to assess HRQoL progression and identify factors affecting SCA patients’ HRQoL. Methods Longitudinal data (three-year follow-up) of 310 S...
As a response to pro-inflammatory signals mesenchymal stem cells (MSCs) secrete agents and factors leading to lymphocyte recruitment, counteracting inflammation, and stimulating immunosuppression. On a molecular level, the signalling mediator TGF-β-activated kinase 1 (TAK1) is activated by many pro-inflammatory signals, plays a critical role in inflammation and regulates innate and adaptive immune responses as well. While the...
Polyploidization is a rare yet sometimes successful way for animals to rapidly create geno‐ and phenotypes that may colonize new habitats and quickly adapt to environmental changes. In this study, we use water frogs of the P elophylax esculentus complex, comprising two species ( P elophylax lessonae , genotype LL ; P elophylax ridibundus , RR ) and various diploid ( LR ) and triploid ( LLR , LRR ) hybrid forms, summarized as P...
Summary The Gram‐positive bacterium B acillus subtilis encounters nutrient limitations and osmotic stress in its natural soil ecosystem. To ensure survival and sustain growth, highly integrated adaptive responses are required. Here, we investigated the system‐wide response of B . subtilis to different, simultaneously imposed stresses. To address the anticipated complexity of the cellular response networks, we combined chemosta...
Poverty and Employment in Forest-Dependent CountiesNARA Subscribed
One of the most controversial aspects of federal and state policies aimed at protecting old-growth ecosystems is the potential effect of job losses on local economic conditions. A fundamental question for historically forest-dependent areas is whether these policies will result in local economic stagnation and enduring pockets of poverty. This study uses monthly, multicounty time series data to estimate a vector autoregressive...
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