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The xiamycins are bioactive indolosesquiterpenoids that have been isolated from actinobacterial strains belonging to the Streptomyces genus. The overexpression of orf2011 , which encodes the LuxR family regulator in a marine Streptomyces strain (HK18) isolated from a hypersaline saltern, significantly increased the production of xiamycin dimers, namely the previously reported dixiamycins A and C ( 3 and 4 ), compared to the wi...
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