This study aimed to identify early carcinogenic markers to predict the hazard potential of mineral fibres using a human 3D bronchial model. Traditional 2D cell models inadequately mimic lung complexity, prompting the use of more physiologically relevant 3D systems. We investigated the effects of crocidolite (CRO) and two size fractions of chrysotile (≤ and > 5 μm length: CHR S and CHR L) to elucidate early toxicological mechan...

We established a high‐resolution calcareous nannofossil biostratigraphy for the late Pliocene–Pleistocene by analyzing a 242 m‐thick, continuous sedimentary succession from Ocean Drilling Program Site 1146, Hole A, in the South China Sea (SCS). A total of 14 calcareous nannofossil datums were detected in the SCS succession. They are, in descending order: first occurrence (FO) of Emiliania huxleyi , last occurrence (LO) of Pseu...