Immune checkpoint inhibitor (ICI)–based combinations represent the standard first-line treatment for metastatic clear cell renal cell carcinoma (mRCC), although robust biomarkers for treatment selection remain undefined. We conducted a systematic review to identify biomarkers assessed in randomized clinical trials (RCTs) on first-line ICI-based regimens. Following PRISMA guidelines, we searched PubMed, Web of Science and Scopu...

Pygmy ( Kogia breviceps ) and dwarf ( Kogia sima ) sperm whales are among the least studied cetaceans due to their elusive behavior and low detectability at sea. Molecular approaches are therefore essential to clarify their taxonomy, population structure, and conservation status. We present new mitochondrial DNA data from stranded K. breviceps and K. sima specimens collected across the eastern North Atlantic, a region previous...

This study investigates the contamination of per- and polyfluoroalkyl substances (PFAS) and organochlorine pesticides (OCPs) in eggs of great tits ( Parus major ) from urban, agricultural, and woodland areas from Italy. PFOS was the most prevalent PFAS, followed by long-chain perfluorocarboxylic acids (PFCAs). Agricultural areas showed the highest PFOS concentrations, while woodland areas exhibited higher concentrations of PFU...

Summary Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is classified according to bowel habits as IBS with constipation (IBS‐C), with diarrhea (IBS‐D), with alternating constipation and diarrhea (IBS‐M), and unsubtyped (IBS‐U). The mechanisms leading to the different IBS forms are mostly unknown. This study aims to evaluate whether specific fecal bacterial taxa and/or short‐chain fatty acids (SC...