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Piscine orthoreovirus‐1 and 3 (PRV‐1, PRV‐3) cause highly prevalent infection in cultured salmonids and can induce heart and skeletal muscle inflammation (HSMI) resulting in economic losses in aquaculture. However, to date, PRV‐1 and PRV‐3 have withstood replication in continuous cell lines. In this study, we used beating heart cell cultures obtained from different developmental stages of rainbow trout ( Oncorhynchus mykiss )...
Use of cardiac cell cultures from salmonids to measure the cardiotoxic effect of environmental pollutantsNARA Subscribed
Environmental stressors such as micro‐ and nanosized plastic particles (MNPs) or crude oil have a detrimental effect on aquatic animals; however, the impact upon the cardiovascular system of fish remains relatively under‐researched. This study presents a novel approach for investigating the effect of crude oil and MNPs on the cardiac system of fish. We used salmonid larvae and cardiac cell cultures derived from hearts of salmo...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...
SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar AtaxiasNARA Subscribed
With SCAview, we present a prompt and comprehensive tool that enables scientists to browse large datasets of the most common spinocerebellar ataxias intuitively and without technical effort. Basic concept is a visualization of data, with a graphical handling and filtering to select and define subgroups and their comparison. Several plot types to visualize all data points resulting from the selected attributes are provided. The...
Correct use of non-indexed eGFR for drug dosing and renal drug-related problems at hospital admissionNARA Subscribed
Purpose Two to seven percent of the German adult population has a renal impairment (RI) with an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m 2 . This often remains unrecognized and adjustment of drug therapy is lacking. To determine renal function in clinical routine, the CKD-EPI equation is used to calculate an indexed eGFR (ml/min/1.73m 2 ). For drug dosing, it has to be individualized to a non-indexed eGFR...
CpG-creating mutations are costly in many human virusesNARA Subscribed
Mutations can occur throughout the virus genome and may be beneficial, neutral or deleterious. We are interested in mutations that yield a C next to a G, producing CpG sites. CpG sites are rare in eukaryotic and viral genomes. For the eukaryotes, it is thought that CpG sites are rare because they are prone to mutation when methylated. In viruses, we know less about why CpG sites are rare. A previous study in HIV suggested that...
The development of synchronous movement by bottlenose dolphins ( Tursiops truncatus )NARA Subscribed
The development of motor synchrony in dolphins has been described qualitatively, but seldom quantified. We provide a detailed description of the development of synchrony in 12 calves for periods ranging from birth to a few days up to 22 wk. We observed the presence of synchrony, relative positions, and proximity and undertook a videotape analysis of one calf for initiations/terminations of synchrony, response time to breaks in...