The principle of dynamic liver function breath tests is founded on the administration of a 13 C-labeled drug and subsequent monitoring of 13 CO 2 in the breath, quantified as time series delta over natural baseline 13 CO 2 (DOB) liberated from the drug during hepatic CYP-dependent detoxification. One confounding factor limiting the diagnostic value of such tests is that only a fraction of the liberated 13 CO 2 is immediately e...

Tetrachlorodibenzo- p -dioxin (TCDD) is a ubiquitous, toxic, persistent and bioaccumulative organic pollutant. TCDD can potentially enter the food chain through contaminated food of animal origin as a consequence of feed contamination. Prediction of the TCDD transfer from feed into animal products is thus important for human health risk assessment. Here, we develop several physiologically based toxicokinetic (PBTK) models of T...