Acute or chronic liver damage can result in Hepatic Encephalopathy (HE), a potentially fatal neuropsychiatric condition that leads to cerebral and neurological alterations. Dapagliflozin (DAPA), an orally active Sodium/Glucose cotransporter 2 inhibitor with long duration of action. The study aim was to evaluate the potential protective impact of DAPA against HE caused by Thioacetamide (TAA) in rats. HE was achieved via a singl...

Despite the beneficial therapeutic effects of tamoxifen (TAMX) against breast cancer, long-term treatment with TAMX enhances the development of metabolic dysfunction-associated steatotic liver disease (MASLD), including steatohepatitis. Bempedoic acid (BA) is a recently approved lipid-lowering drug for dyslipidemia. Our study aimed to examine the potential impact of BA against TAMX-induced steatohepatitis in rats and underline...

This study aimed to investigate the impact of ambient lead (Pb) exposure on progesterone (P 4 ) and pregnancy-associated glycoprotein 1 (PAG1) and their relationship with abortion in Egyptian Zaraibi goats ( C. hircus ). To achieve this, 40 female goats (does) were mated with highly fertile male goats, resulting in a total of 28 pregnant goats. Eight of them aborted, and each of the 12 pregnant goats gave birth to one kid, whe...