The intensive mariculture of S. aurata can promote aquaculture development, although it can also pose challenges because of predatory behavior and environmental stressors caused by intensification. The objective of this study is to alleviate stress and prevent cannibalism, thereby improving the fish’s performance and welfare. A 90-day growth experiment investigated the dietary inclusion of melatonin (ML) on Sparus aurata perfo...

Lorundrostat, a novel selective aldosterone synthase inhibitor, has emerged as a potential treatment for uncontrolled hypertension. However, a comprehensive summary of its efficacy and safety profile is currently lacking. This meta-analysis aims to synthesize evidence from published randomized controlled trials (RCTs) to evaluate the clinical benefits and risks of lorundrostat in this patient population. Following the PRISMA g...

Cyclophosphamide (CP) is an anti-cancer medication that also treats chronic inflammatory illnesses caused by the immune system. Although CP is widely used, it can occasionally have limited therapeutic efficacy due to its significant combined toxicities. Ovarian damage caused by CP is a major problem for patients, and premature ovarian failure (POF) is a serious side effect of CP that commonly affects female patients. Mechanist...

Spacers, when used with pressurized metered dose inhalers (pMDIs), enhance aerosol drug delivery and address coordination challenges during inhalation. This study aimed to compare the efficacy of emergency spacers with traditional spacers in delivering salbutamol aerosol from pMDIs. The total emitted dose (TED) and particle size distribution of salbutamol were determined using an Andersen MKII cascade impactor. The study evalu...

Salinization, as a serious climate change phenomenon, continues to cause critical issues for soils and crops. Abundance of genetic diversity of plants could contribute in solving the impacts of salinity. However, the relations between physiological and molecular traits of plant species need deep investigation and interpretation. Pot experiments were conducted in the greenhouse to investigate the difference in behavior between...

The present study outlines an easy, cheap, and environmentally friendly way to make Staphylococcus aureus -mediated bimetallic silver-copper nanocomposites (Ag/Cu) that can fight cancer and germs. The gram-positive S. aureus synthesized Ag, Cu, and their bi-metallic nanocomposites extracellularly. We aimed to prepare the bimetallic nanocomposite in two different ways, and we compared them in terms of characterization and biolo...

Parkinson’s disease (PD) is the second most common progressive age-related neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT signaling activation in the treatment of neurodegenerative disorders. PI3K/AKT signaling can be activated via cAMP-dependent pathways achieved by phosphodiesterase 4 (PDE4) inhibition. Roflumilast is a well-known PDE4 inhibitor that is currently used in the treatment of ch...

Heavy metal toxicity is an exponentially growing health problem. In this study, we aimed to assess the protective properties of propolis and royal jelly against cadmium adverse effects. Thirty-two adult male rats were included in our study; kidney and liver functions, histopathological changes, and the level of oxidative stress were evaluated in rats exposed to a daily dose of 4.5 mg cadmium per kilogram of body weight for 1 m...