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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Species‐specific interactions with apex carnivores yield unique benefits and burdens for mesocarnivoresNARA Subscribed
Mesocarnivores navigate a complex risk–reward continuum in ecosystems shared with their apex counterparts, balancing scavenging opportunities with risks of mortality. However, the risks to mesocarnivores in multi‐carnivore systems are not uniform; they can vary with specific apex–meso pairings. Using remote cameras and GPS‐telemetry, we examined space‐use, temporal activity, fine‐scale interactions, and scavenging behaviors of...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Ocean Census is a new Large-Scale Strategic Science Mission aimed at accelerating the discovery and description of marine species. This mission addresses the knowledge gap of the diversity and distribution of marine life whereby of an estimated 1 million to 2 million species of marine life between 75% to 90% remain undescribed to date. Without improved knowledge of marine biodiversity, tackling the decline and eventual extinct...
Invertebrates comprise the most diversified animal group on Earth. Due to their long evolutionary history and small size, invertebrates occupy a remarkable range of ecological niches, and play an important role as “ecosystem engineers” by structuring networks of mutualistic and antagonistic ecological interactions in almost all terrestrial ecosystems. Urban forests provide critical ecosystem services to humans, and, as in othe...
Understanding the abundance and distribution of fish in tidal energy streams is important for assessing the risks presented by the introduction of tidal energy devices into the habitat. However, tidal current flows suitable for tidal energy development are often highly turbulent and entrain air into the water, complicating the interpretation of echosounder data. The portion of the water column contaminated by returns from entr...
Current carbon prices do not stack up to much land use change, despite bundled ecosystem service co‐benefitsNARA Subscribed
Biological sources of carbon sequestration such as revegetation have been highlighted as important avenues to combat climate change and meet global targets by the global community including the Paris Climate Agreement. However, current and projected carbon prices present a considerable barrier to broad‐scale adoption of tree planting as a key mitigation strategy. One avenue to provide additional economic and environmental ince...
A coherent high‐precision radiocarbon chronology for the Late‐glacial sequence at Sluggan Bog, Co. Antrim, Northern IrelandNARA Subscribed
Seventy‐five radiocarbon dates are presented from Sluggan Bog in Co. Antrim, Northern Ireland. The Holocene peats are underlain by Late‐glacial sediments, which also appear to have accumulated largely in a mire environment. The radiocarbon dates, from the Late‐glacial and early Holocene part of the profile, were obtained from the humic and humin fractions of the sedimentary matrix, and from plant macrofossils. The last‐named w...
Apoptosis and chemoresistance in transgenic cancer modelsNARA Subscribed