Sebastian Fischer results 42
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New Research Perspectives in Light of Dense Cross-Border Experiments in West Bohemia and Vogtland RegionsNARA Subscribed
The Eger Large-N International Seismic Experiment (ELISE) is a major cross-border project deploying a temporary network of over 300 broadband and short-period seismic stations in the West Bohemia/Vogtland region, located at the border of Czechia and Germany. This experiment offers new research opportunities in one of the most seismically and geodynamically active intraplate regions in Europe, characterized by recurrent earthqu...
Modeling lactate threshold in cycling—influence of sex, maximal oxygen uptake, and cost of cycling in young athletesNARA Subscribed
Purpose Understanding physiological determinants of lactate threshold 2 (LT2) is crucial for tracking adaptations and deriving individualized training recommendations in cycling. Therefore, the study investigated: 1. the accuracy of modeling power output at LT2 in young athletes of both sexes using maximal oxygen uptake ( $${\dot{V}}\textrm{O}_{2_\textrm{peak}}$$ V ˙ O 2 peak ), fractional utilization of $${\dot{V}}\textrm{O}_...
Dominance and rarity in tree communities across the globe: Patterns, predictors and threatsNARA Subscribed
Aim Ecological and anthropogenic factors shift the abundances of dominant and rare tree species within local forest communities, thus affecting species composition and ecosystem functioning. To inform forest and conservation management it is important to understand the drivers of dominance and rarity in local tree communities. We answer the following research questions: (1) What are the patterns of dominance and rarity in tree...
Loss-of-function variants affecting the STAGA complex component SUPT7L cause a developmental disorder with generalized lipodystrophyNARA Subscribed
Generalized lipodystrophy is a feature of various hereditary disorders, often leading to a progeroid appearance. In the present study we identified a missense and a frameshift variant in a compound heterozygous state in SUPT7L in a boy with intrauterine growth retardation, generalized lipodystrophy, and additional progeroid features. SUPT7L encodes a component of the transcriptional coactivator complex STAGA. By transcriptome...
NIKE-MED – Nachhaltige Interdisziplinarität in Komplexen Einsätzen unter Tage – MEDical TreatmentNARA Subscribed
Zusammenfassung Das Projekt NIKE-MED zielt darauf ab, die Effizienz und Effektivität der Einsatzkräfte bei der Bewältigung von Notfällen insbesondere bei Großschadensereignissen zu erhöhen, um die Sicherheit der betroffenen Personen zu gewährleisten. Komplexe Einsätze unter Tage sind mit einem Massenanfall von Opfern mit sehr spezifischen Verletzungsmustern, die man aus bewaffneten Konflikten kennt (Vergiftungen, Verbrennungen...
The EnMAP imaging spectroscopy mission towards operationsNARA Subscribed
EEG-based sensory testing reveals altered nociceptive processing in elite endurance athletesNARA Subscribed
Increased exercise loads, as observed in elite athletes, seem to modulate the subjective pain perception in healthy subjects. The combination of electroencephalography (EEG) and standardized noxious stimulation can contribute to an objective assessment of the somatosensory stimulus processing. We assessed the subjective pain ratings and the electroencephalogram (EEG)-based response after standardized noxious mechanical and the...
Galectin-4 (Gal-4) is a member of the galectin family, which have been identified as galactose-binding proteins. Gal-4 possesses two tandem repeat carbohydrate recognition domains and acts as a cross-linking bridge in sulfatide-dependent glycoprotein routing. We herein document its upregulation in osteoarthritis (OA) in correlation with the extent of cartilage degradation in vivo. Primary human OA chondrocytes in vitro respond...
Organizational and technical approaches have proven successful in increasing the performance and preventing risks at socio-technical systems at all scales. Nevertheless, damaging events are often unavoidable due to a wide and dynamic threat landscape and enabled by the increasing complexity of modern systems. For overall performance and risk control at the system level, resilience can be a versatile option, in particular for r...
Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyon...
Intraclonal competitive fitness of longitudinal cystic fibrosis Pseudomonas aeruginosa airway isolates in liquid culturesNARA Subscribed
Summary The metabolically versatile Pseudomonas aeruginosa inhabits biotic and abiotic environments including the niche of cystic fibrosis (CF) airways. This study investigated how the adaptation to CF lungs affects the within‐clone fitness of P. aeruginosa to grow and persist in liquid cultures in the presence of the clonal ancestors. Longitudinal clonal P. aeruginosa isolates that had been collected from 12 CF donors since t...