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Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP2 bindingNARA Subscribed
The inwardly rectifying potassium current of the cardiomyocyte (I K1 ) is the main determinant of the resting potential. Ion channels Kir2.1, Kir2.2, and Kir2.3 form tetramers and are the molecular correlate of macroscopic I K1 current. Verapamil is an antiarrhythmic drug used to suppress atrial and ventricular arrhythmias. Its primary mechanism of action is via blocking calcium channels. In addition, it has been demonstrated...
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