A series of triaxial compression tests was performed on a natural sand-fines mixture under both drained and undrained conditions at initial confining pressures ranging from 20 to 300 kPa. The tests aimed to better understand the mechanical behaviour of the soil at low stress levels. Additionally, images of the soil fabric were taken using a µ CT device, revealing that the fabric was characterised by the sand grains being fully...

The determination of a tailored anti-drug antibody (ADA) testing strategy is based on the immunogenicity risk assessment to allow a correlation of ADAs with changes to pharmacokinetics, efficacy, and safety. The clinical impact of ADA formation refines the immunogenicity risk assessment and defines appropriate risk mitigation strategies. Health agencies request for high-risk biotherapeutics to extend ADA monitoring for patient...