Pertussis, also known as whooping cough, is a highly infectious respiratory disease caused by the bacterium Bordetella pertussis . The bacterial virulence factor, pertussis toxin (PT), is associated with the manifestation of the characteristic symptoms of pertussis and the severe form of this disease. Increasing case numbers and the lack of treatment options highlight the need to develop novel pharmacological strategies, e.g.,...

Endogenous antimicrobial peptides (AMPs) play a key role in the host defense against pathogens. AMPs attack pathogens preferentially at the site of entry to prevent invasive infection. Mycobacterium tuberculosis ( Mtb ) enters its host via the airways. AMPs released into the airways are therefore likely candidates to contribute to the clearance of Mtb immediately after infection. Since lysozyme is detectable in airway secretio...

In this study, the effects of fully coupling the atmosphere, waves, and ocean compared with two-way-coupled simulations of either atmosphere and waves or atmosphere and ocean are analyzed. Two-year-long simulations (2017 and 2018) are conducted using the atmosphere–ocean–wave (AOW) coupled system consisting of the atmosphere model CCLM, the wave model WAM, and the ocean model NEMO. Furthermore, simulations with either CCLM and...