Nuclear energy plays a crucial role as a clean energy source in modern society. The use of nuclear energy will result in the generation of a large amount of radioactive nuclear wastewater. Separation of nuclides from radioactive wastewater is crucial for the safe disposal of nuclear wastes and the sustainable development of resources. However, it remains a great challenge to achieve precise separation between different radionu...

The production of high-purity mRNA drug substances by in vitro transcription utilizing T7 RNA polymerase can be challenging due to the formation of product related impurities. These include double-stranded RNA, fragmented mRNA, and uncapped transcripts. This review examines the known mechanisms underlying the formation of the major mRNA impurities during in vitro transcription (IVT), their biological impact and strategies for...

Background Brucellosis is one of the most severe Class B infectious diseases prevalent in the agricultural and pastoral areas of northern China. Current attenuated live vaccines (e.g., M5, S19) have defects such as residual virulence, causing abortion in pregnant animals, and the inability to differentiate between natural infection and vaccination (DIVA). Methods Relying on the ABSL-3 laboratory of the Inner Mongolia Center fo...