Purpose Polycaprolactone nanoparticles (PCLNPs) are biodegradable carriers widely investigated for drug delivery applications. Their hydrophobic nature and high encapsulation efficiency make them ideal for sustained drug release. This study aimed to encapsulate licofelone (LF), a dual COX/5-LOX inhibitor, within PCLNPs to enhance its therapeutic efficacy for osteoarthritis treatment through transdermal administration. Methods...

This study investigated the interactive effects of dietary fat levels and selenium–vitamin E (Se + VE) supplementation on the growth performance, antioxidant status, immune response, and disease resistance of Oreochromis niloticus . The fish were fed diets containing 5%, 10%, or 15% lipids with or without Se + VE supplementation over a 60-day experimental period. Growth metrics, including final weight, weight gain, average dai...

Intensified aquaculture practices have increased the vulnerability of farmed fish to infectious pathogens, highlighting nutritional strategies to increase health and reduce antibiotic reliance. Dietary antioxidants such as Nigella sativa (NI) and carvacrol (CA) have shown potential as functional feed additives because of their synergistic effects under bacterial challenge. This study evaluated whether dietary supplementation w...

Due to the damaging effects of root-knot nematodes on crops and the dangerous effects of chemical nematicides on both people and the environment in Egypt, the purpose of this study was to assess the power of polysaccharides and polyphenol extracts as well as their nano-forms from marine algae ( Laurencia papillosa and Dilophys fasciola ) used as eco-friendly alternatives for the control of Meloidogyne incognita . The nano-form...

This study’s goal was to assess the catfish’s response to exposure to monoaromatic petroleum hydrocarbons (benzene, toluene, and xylene) and its recovery after exposure using oxidative stress, histopathological, and immunological changes as biomarkers. Four groups: one as control and other three exposed to benzene (0.762 ng/L), toluene (26.614 ng/L), and xylene (89.403 ng/L), respectively, for 30 days and then recovery period...

Prolonged dexamethasone (DEX) administration causes skeletal muscle atrophy through induction of both oxidative stress and mitochondrial dysfunction. Lipoxin A4 (LXA4) is a recognized antioxidant but its effect against DEX-induced muscle atrophy has not been studied yet. This study aimed to assess the potential ameliorating effect of LXA4 on DEX-induced muscle atrophy and investigate the possible involvement of the mitochondri...