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NARA Subscribed1
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Springer Nature1
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GeroScience1
Publication Year
20241
Shane Profio results 1 · Newest (Page 1/1, per page 25)
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Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophyNARA Subscribed
GeroScience · 2024 · Vol. 46 · Issue 5 · Springer
Huanhuan Liu; Trent Davis; Silvana Duran-Ortiz; Tom Martino; Austin Erdely; Shane Profio; Benjamin Osipov; Gabriela G. Loots; Darlene E. Berryman; Patrick M. O’Connor; John J. Kopchick; Shouan Zhu
Excessive growth hormone (GH) has been shown to promote joint degeneration in both preclinical and clinical studies. Little is known about the effect of disrupted GH or GH receptor (GHR) on joint health. The goal of this study is to investigate joint pathology in mice with either germline ( GHR -/- ) or adult inducible ( iGHR -/- ) GHR deficiency. Knee joints from male and female GHR -/- and WT mice at 24 months of age were pr...
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