Background Circulating tumour cells (CTCs) are key mediators of metastasis and exhibit marked phenotypic plasticity driven by epithelial-to-mesenchymal transition (EMT). Traditional marker-based CTC isolation approaches rely on epithelial marker expression, which may fail to capture mesenchymal and hybrid CTC subpopulations. Hybrid CTCs remain poorly characterised in colorectal cancer (CRC). This study explored transcriptional...

Purpose Proton pump inhibitors (PPIs) reduce acid secretion in the stomach and rank as one of the most widely used acid-suppressing medicines globally. While PPIs are safe in the short-term, emerging evidence shows risks associated with long-term use. Current evidence on global PPI use is scarce. This systematic review aims to evaluate global PPI use in the general population. Methods Ovid MEDLINE, Embase, and International Ph...