Objective and design To elucidate Sirt1’s role in gouty arthritis inflammation and its potential mechanisms. Material Constructed murine models of gouty arthritis and conducted THP-1 cell experiments. Treatment 1 mg of MSU crystals injected into mice ankle joints for a 72-h intervention. After a 3-h pre-treatment with Sirt1-specific inhibitor (EX527) and agonist (SRT2104), inflammation was induced for 21 h using lipopolysaccha...

Hadal trenches remain one of the unexplored ocean ecosystems due to the challenges of sampling at great depths. It is still unclear how a faunal community changes from the abyssal to the hadal zone, and which environmental variables are the key impacting factors. In this study, nine dives of the Human Occupied Vehicle (HOV) “ JIAOLONG ” were conducted from abyssal to hadal depths (4,435–6,796 m) in the Yap Trench on the southe...