Rationale Chronic stress is a major precipitating factor for mood disorders, which are diagnosed twice as frequently in women as in men. However, most preclinical models of chronic social defeat stress have limited use in females due to reduced aggression toward female intruders. The chronic non-discriminatory social defeat stress (CNSDS) model addresses these limitations by enabling the study of stress susceptibility across s...

Harmful algal blooms (HABs) are a growing environmental concern that require better understanding, prediction, and study. Even though photosynthesizing algae produce 70% of atmospheric oxygen, their unexpected outbreaks can harm the environment. A delicate interplay of various environmental factors drives the intricate dynamics of algal blooms. Artificial neural network (ANN) models provide profound insights into the nonlinear...

BCS class II candidates pose challenges in drug development due to their low solubility and permeability. Researchers have explored various techniques; co-amorphous and solid dispersion are major approaches to enhance in-vitro drug solubility and dissolution. However, in-vivo oral bioavailability remains challenging. Physiologically based pharmacokinetic (PBPK) modeling with a detailed understanding of drug absorption, distrib...