Purpose The DANFLU-1 trial suggested lower incidence of hospitalizations for pneumonia and influenza, respiratory disease and all-cause mortality among older adults receiving high-dose (HD-IV) versus standard-dose (SD-IV) influenza vaccine. This study assessed the relative effectiveness of HD-IV versus SD-IV according to comorbidity in elderly individuals. Methods This was a post-hoc analysis of the DANFLU-1 randomized control...

Environmental variation is an important factor in crop yield variability, especially in large agricultural experiments such as breeding trials. This study explores whether prior knowledge of the spatial field trends can enhance phenotypic prediction accuracy by choice of experimental design and statistical analysis. Using data from three breeding trials and a simulation study with eight field trends, we compared five experimen...