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Springer Nature1
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Molecular and Cellular Biochemistry1
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20251
Silvia Codenotti results 1 · Newest (Page 1/1, per page 25)
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Synthetic inhibition of the SUMO pathway by targeting the SAE1 component via TAK-981 compound impairs growth and chemosensitizes embryonal and alveolar rhabdomyosarcoma cell linesNARA Subscribed
Molecular and Cellular Biochemistry · 2025 · Vol. 480 · Issue 10 · Springer
Silvia Codenotti; Volker M. Lauschke; Emma V. Casella; Daniel C. Andersson; Alessandro Fanzani; Stefano Gastaldello
Rhabdomyosarcoma (RMS) is a highly aggressive pediatric soft tissue sarcoma with limited therapeutic options, particularly for cases resistant to conventional treatments. The SUMOylation pathway, which plays a key role in regulating the cell cycle, apoptosis, and transcription, has emerged as a potential therapeutic target in RMS. Elevated levels of SUMO1 and SUMO2/3 conjugates in RMS cell lines, compared to normal human skele...
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