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The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
How to get to the N – a call for interdisciplinary research on organic N utilization pathways by plantsNARA Subscribed
Background and aims While nitrogen (N) derived from soil organic matter significantly sustains agricultural plants, the complexities of organic N utilization pathways remain poorly understood. Knowledge gaps persist regarding diverse organic N pools, the microbial processes in N mineralization, and how plants shape the N-mineralizing microbial community through root exudation. Results To address these gaps, we propose an integ...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Genetic differentiation of wild boar populations in a region affected by African swine feverNARA Subscribed
In the European Union, African swine fever (ASF) affects wild boar ( Sus scrofa ) populations in several Member States. Knowledge of population connectivity is important for the implementation of control measures, in particular the establishment of effective barriers. Population genetic comparisons of neighbouring populations can be very helpful in this respect. The present study investigated the genetic differentiation of wil...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
MOG-Specific T Cells Lead to Spontaneous EAE with Multilocular B Cell Infiltration in the GF-IL23 ModelNARA Subscribed
Although IL-23 and downstream signal transduction play essential roles in neuroinflammation, the local impact of IL-23 in multiple sclerosis is still not fully understood. Our previous study revealed that the central nervous system (CNS)-restricted expression of IL-23 in a mouse model with astrocyte-specific expression of IL-23, called GF-IL23 mice, leads to spontaneous formation of infiltrates in the brain, especially in the...
Telomeres are protective caps at the end of eukaryotic chromosomes that shorten with age and in response to stressful or resource‐demanding conditions. Their length predicts individual health and lifespan across a wide range of animals, but whether the observed positive association between telomere length and lifespan is environmentally induced, or set at conception due to a shared genetic basis, has not been tested in wild an...
The initial phase of the Hönne Valley Reef at Binolen (northern Rhenish Massif, Middle Devonian)NARA Subscribed
The Hagen-Balve Reef Complex of the northern Rhenish Massif, Germany, is one of the best examples for the globally widespread Givetian to Frasnian reefs. At its eastern end, in the Hönne Valley, it reaches up to 1000 metres in thickness. In general, there is limited knowledge concerning the faunas and palaeoecology of Rhenish initial reef phases. A unique section at Binolen exposes the sharp boundary between the underlying, si...
Machine learning techniques to characterize functional traits of plankton from image dataNARA Subscribed
Plankton imaging systems supported by automated classification and analysis have improved ecologists' ability to observe aquatic ecosystems. Today, we are on the cusp of reliably tracking plankton populations with a suite of lab‐based and in situ tools, collecting imaging data at unprecedentedly fine spatial and temporal scales. But these data have potential well beyond examining the abundances of different taxa; the individua...
Binding of HasA by its transmembrane receptor HasR follows a conformational funnel mechanismNARA Subscribed
HasR in the outer membrane of Serratia marcescens binds secreted, heme-loaded HasA and translocates the heme to the periplasm to satisfy the cell’s demand for iron. The previously published crystal structure of the wild-type complex showed HasA in a very specific binding arrangement with HasR, apt to relax the grasp on the heme and assure its directed transfer to the HasR-binding site. Here, we present a new crystal structure...
From January through March 2017, a series of extreme precipitation events occurred in coastal Peru, causing severe floods with hundreds of human casualties and billions of dollars in economic losses. The extreme precipitation was a result of unusually strong recurrent patterns of atmospheric and oceanic conditions, including extremely warm coastal sea surface temperatures (SST) and weakened trade winds. These climatic features...
Telomere length is repeatable, shortens with age and reproductive success, and predicts remaining lifespan in a long‐lived seabirdNARA Subscribed
Telomeres are protective caps at the end of chromosomes, and their length is positively correlated with individual health and lifespan across taxa. Longitudinal studies have provided mixed results regarding the within‐individual repeatability of telomere length. While some studies suggest telomere length to be highly dynamic and sensitive to resource‐demanding or stressful conditions, others suggest that between‐individual dif...
The global structure of marine cleaning mutualistic networksNARA Subscribed
Aim We studied the underlying biotic and abiotic drivers of network patterns in marine cleaning mutualisms (species feeding upon ectoparasites and injured tissues of others) at large spatial scales. Location Eleven marine biogeographical provinces. Time period 1971–2018. Major taxa studied Reef fish and shrimps. Methods We combined field and literature data to test whether recurrent patterns in mutualistic networks (nestedness...
Telomere length reflects reproductive effort indicated by corticosterone levels in a long‐lived seabirdNARA Subscribed
Telomere length ( TL ) is a candidate biomarker of ageing and phenotypic quality, but little is known of the (physiological) causes of TL variation. We previously showed that individual common terns Sterna hirundo with high reproductive success had short telomeres independent of age, and this pattern was particularly strong in the longer telomeres of the within‐individual TL distribution. To test whether this relation can be a...
Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long‐lived seabirdNARA Subscribed
Telomeres, DNA ‐protein structures at chromosome ends, shorten with age, and telomere length has been linked to age‐related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. We measured telomeres in erythrocytes of wild common terns Sterna hirundo using terminal restriction fragment analysi...
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