Simon C. Barry results 16
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LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistanceNARA Subscribed
Cancer stem cells play an important role in tumor progression and chemotherapy resistance. Leucine-rich G repeat-containing protein-coupled receptor 5 (LGR5) has been identified as a cancer stem cell marker in several cancer types. LGR5 is involved in cancer development and progression via several pathways including WNT/β-catenin signaling pathway. LGR5 plays a role in tumor progression by promoting cancer cell migration, inva...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...
On inferring population trends of mobile waterbirds from aerial transect surveys in variable environmentsNARA Subscribed
Monitoring waterbird populations in Australia is challenging for reasons of counting logistics, and because population aggregation and dispersion can shift rapidly in response to large spatio-temporal variations in resource availability. The East Australian Waterbird survey has conducted annual, aerial, systematic counts of waterbirds over eastern Australia for almost 40 years. It was designed to monitor waterbird populations...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
When exotic introductions fail: updating invasion beliefsNARA Subscribed
Decisions regarding invasive risk of exotic species are often based on species distribution models projected onto the recipient region of interest. Such projections are essentially a measure of prior belief in the ability of an organism to invade. Whilst many decisions are made on the basis of such projections, it is less clear how such prior belief may be empirically modified on the basis of data, in particular introduction e...
The TEASI model is presented in Leung et al. (2012; TEASIng apart alien species risk assessments: a framework for best practices. Ecol. Lett ., 15 , 1475) as a framework for best practice in alien species risk assessment. This is not supported by the paper's review as it does not define good, bad or best practice and therefore cannot logically make this claim.
Large‐scale spatial and temporal dynamics of the vulnerable and highly mobile superb parrotNARA Subscribed
Aim To investigate the spatial and temporal dynamics of the vulnerable and highly mobile superb parrot ( Polytelis swainsonii ) across its range in south‐eastern mainland Australia. Location South‐eastern Australia (27°–37° S latitude and 141°–151° E longitude). Methods We used generalized additive models (GAMs) to model time‐specific bird atlas occurrence data against time‐specific plant productivity data, plus a range of env...
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